Raheem Sterling will stand in for Lucas Leiva who picked up his fifth yellow card of the season against Sunderland last week.
Victor Moses starts against his former club while Luis Suarez and Daniel Sturridge continue their partnership up front.
Stuart O'Keefe starts for the first time in a Premier League game after Kagisho Dikgacoi suffered an injury in midweek; Damien Delaney returns while Danny Gabbidon drops to the bench.
Liverpool: Mignolet, Toure, Skrtel, Sakho, Henderson, Enrique, Gerrard, Sterling, Moses, Sturridge, Suarez Subs: Jones, Ibe, Wisdom, Agger, Aspas, Ilori, Alberto
Crystal Palace: Speroni, Ward, Mariappa, Delaney, Moxey, Jedinak, O'Keefe, Puncheon, Kebe, Jerome, Chamakh Subs: Price, Inniss, Campana, Guedioura, Bolasie, Gayle, Phillips
