The Senegal international scored two first-half goals inside 138 seconds to all but end Spurs' title challenge and secure Liverpool's first win of 2017.
Southampton's 4-0 thrashing of Sunderland will follow soon after, with January signing Manolo Gabbiadini also netting a first-half double.
Alexis Sanchez scored two controversial goals as Arsenal sneaked past a resilient Hull City side to keep pace with second-placed Spurs.
Manchester United boosted their own top-four chances with a comfortable win over Watford while West Ham fans will have to wait to see Gareth McAuley head home to deny another three points for their team against West Brom.
Eagles fans would be forgiven for not waiting up to see Crystal Palace's relegation fears stepped up another notch thanks to Joe Allen's second-half winner for Stoke City in the penultimate slot of the evening.
Middlesbrough and Everton's bore draw is last on the menu.
FULL MOTD RUNNING ORDER (10:30pm-11:50pm)
Sunderland 0 Southampton 4
Middlesbrough 0 Everton 0
In Pictures | Arsenal vs Hull | 11/02/2017
In Pictures | West Ham vs West Brom | 11/02/2017
Middlesbrough 0 Everton 0
Sunderland 0 Southampton 4
In Pictures | Manchester United vs Watford | 11/02/2017
UPCOMING FIXTURES
Sunday 12th February 2017
1330 | Burnley vs Chelsea
In Pictures | Southampton vs West Ham | 04/02/2017
1600 | Swansea vs Leicester
