Manchester United manager Louis van Gaal has made four changes to the side which beat West Brom before the international break.
Amid something of an injury crisis in the attacking department at Old Trafford, the Dutchman has opted to start Memphis Depay as an out-and-out striker.
Indeed, injury to both Wayne Rooney and Anthony Martial has seen both drop out of the side, while Marouane Fellaini has also suffered a setback in recovery from an injury sustained before the domestic calendar made way for international football.
As such, Ander Herrera comes into the side, as does Morgan Schneiderlin - for Michael Carrick - and Marcos Rojo makes way for Phil Jones.
Youngsters Sean Goss and Marcus Rashford make the United bench for the first time.
There is one change for the hosts as Jose Jurado comes in for Nathan Ake, while Belgian striker Obbi Oularé has been named among the substitutes for the first time.
Watford: Gomes, Nyom, Cathcart, Britos, Anya, Capoue, Watson, Jurado, Deeney, Abdi, Ighalo. Subs: Oulare, Paredes, Ake, Guedioura, Ibarbo, Diamanti, Arlauskis.
Man Utd: De Gea, Jones, Smalling, Blind, Young, Schweinsteiger, Schneiderlin, Mata, Ander Herrera, Lingard, Depay. Subs: Rojo, Romero, McNair, Darmian, Rashford, Andreas Pereira, Goss.
Referee: Robert Madley (West Yorkshire)
