The Hammers travel to AZ Alkmaar on Thursday with a 2-1 lead from the first leg and David Moyes has rested key players at the Gtech Community Stadium.
Declan Rice and Kurt Zouma are among the big names on the bench, while Michail Antonio is not even in the squad.
Flynn Downes and Danny Ings are among the players to come into the team.
Vladimir Coufal remains sidelined.
Moyes said: “He is starting to do some light jogging. And so, he’s improving but he has just got a slight hamstring tweak and you are always not sure when the right time is [to bring him back to for match action].
“But he is a boy who wants to play and wants to get back quickly so it is always a positive sign and hopefully, we get him back soon too.”
Angelo Ogbonna is still struggling with illness.
Moyes said: “I am not sure if [Angelo will be available on Sunday]. He is still not feeling great, so we will need to wait and see how Angelo is. He has got the bug that has been going around here.
Confirmed West Ham XI: Fabianksi; Johnson, Aguerd, Ogbonna, Emerson; Soucek, Downes; Cornet, Lanzini, Fornals; Ings
Subs: Areola, Creswell, Zouma, Kehrer, Rice, Paqueta, Benrahma, Mubama, Bowen
