Tottenham and Manchester United will face off at Wembley for a place in the FA Cup final, with Chelsea and Southampton competing in the other clash.
United are aiming to match Arsenal's record number of 13 wins, having both finished as runners-up seven times and now face Spurs at their temporary home.
Spurs and United have already met twice this season, with Jose Mourinho & Co. coming out on top at Old Trafford in the Premier League in October before being dismantled at Wembley in January with Christian Eriksen scoring after just 10 seconds.
Their previous FA Cup meeting came in the fourth round in 2008-09 as Paul Scholes and Dimitar Berbatov cancelled out Roman Pavlychenko's opener. The last time Spurs beat United in the FA Cup, Ossie Ardiles scored the only goal in a 1-0 third-round replay win at Old Trafford in 1979-80.
Chelsea have won 12 of their previous 22 semi-final outings. The last three times the Blues knocked Leicester City out of the FA Cup, they went on to win the competition.
Tottenham have won the competition eight times, one more than Chelsea, but have lost 11 of their 20 appearances in the last four. Once in the final, though, they have won eight of nine.
Southampton are set to make their 12th semi-final outing, winning just four of the previous 11. They last made the FA Cup semi-final in 2002-03 where they beat Watford at Villa Park before losing to Arsenal at the Millennium Stadium.
In Pictures | Leicester vs Chelsea, FA Cup quarter-final | 18/03/2018
Saints have lost in their previous four meetings with Chelsea, conceding nine goals, and meet again in the Premier League on April 14.
The two teams last met in the FA Cup in January 2013, with Chelsea running out convincing 5-1 winners at St. Mary's as Demba Ba scored twice on this debut.
