The award was announced as part of the New Year Honours alongside knighthoods for The Beatles' drummer Ringo Starr and Bee Gee Barry Gibb.
Wiley, whose real name is Richard Cowie, shared his approval on Instagram, writing "Big up the Queen thank you" after the honour was made public on Friday night.
Meanwhile a host of artists congratulated the 38-year-old MC on social media.
DJ Target tweeted: "So proud of my brother @WileyUpdates receiving an MBE. Absolutely Amazing", while MC CASSisDEAD wrote: "Congratulations...huge moment for you and all of us."
On Instagram, rapper AM SNiPER said he was "mad proud" of the artist, artist Yxng Bane wrote: "Legend bro, legend" and DJ Locksmith, member of drum-and-bass band Rudimental, congratulated the star.
Mobo awards founder Kanya King tweeted her congratulations, while musician Example wrote: "you better turn up to receive this...congrats bro."
BBC 1Xtra host Twin B tweeted: "Flipppppin ek! That's a big deal broseph! Congrats G! You need to figure out the schwaaag for the palace visit lol!
Producer Zdot tweeted: "Congrats on the MBE @WileyUpdates fully deserved".
Meanwhile Manchester grime collective Virus Syndicate wrote: "Wow massive congrats to the godfather @WileyUpdates he inspired us and many others like us. Big love my don."
Additional reporting by the Associated Press
